CHIARA VITALE BROVARONE

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+39 0110904564 / 4564 (DISAT)

+39 0110904716 / 4716 (DISAT)

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Most recent publications

Fiorilli, S.; Pagani, M.; Boggio, E.; Gigliotti, C. L.; Dianzani, C.; Gauthier, R.; ... (2021)
Sr-containing mesoporous bioactive glasses bio-functionalized with recombinant ICOS-Fc: An in vitro study. In: NANOMATERIALS, vol. 11, pp. 1-23. ISSN 2079-4991 Download fulltext
Banche Niclot, F.; Montalbano, G.; Fiorilli, S.; Vitale Brovarone, C. (2021)
PEG-coated large mesoporous silicas as smart platform for protein delivery and their use in a collagen-based formulation for 3d printing. In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 22, pp. 1-18. ISSN 1661-6596 Download fulltext
Molino, Giulia; Montalbano, Giorgia; Pontremoli, Carlotta; Fiorilli, Sonia; Vitale ... (2020)
Imaging techniques for the assessment of the bone osteoporosis-induced variations with particular focus on micro-ct potential. In: APPLIED SCIENCES, vol. 10, pp. 1-27. ISSN 2076-3417 Download fulltext
Melo, P.; Naseem, R.; Corvaglia, I.; Montalbano, G.; Pontremoli, C.; Azevedo, A.; ... (2020)
Processing of Sr2+ Containing Poly L-Lactic Acid-Based Hybrid Composites for Additive Manufacturing of Bone Scaffolds. In: FRONTIERS IN MATERIALS, vol. 7. ISSN 2296-8016 Download fulltext
Paterson, T. E.; Bari, A.; Bullock, A. J.; Turner, R.; Montalbano, G.; Fiorilli, S.; ... (2020)
Multifunctional Copper-Containing Mesoporous Glass Nanoparticles as Antibacterial and Proangiogenic Agents for Chronic Wounds. In: FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, vol. 8. ISSN 2296-4185 Download fulltext
Zheng, K.; Torre, E.; Bari, A.; Taccardi, N.; Cassinelli, C.; Morra, M.; Fiorilli, S.; ... (2020)
Antioxidant mesoporous Ce-doped bioactive glass nanoparticles with anti-inflammatory and pro-osteogenic activities. In: MATERIALS TODAY BIO, vol. 5. ISSN 2590-0064 Download fulltext
Licini, Caterina; Montalbano, Giorgia; Ciapetti, Gabriela; Cerqueni, Giorgia; Vitale ... (2020)
Analysis of multiple protein detection methods in human osteoporotic bone extracellular matrix: From literature to practice. In: BONE, vol. 137. ISSN 8756-3282 Download fulltext
Borciani, Giorgia; Montalbano, Giorgia; Baldini, Nicola; Cerqueni, Giorgia; Vitale ... (2020)
Co–culture systems of osteoblasts and osteoclasts: Simulating in vitro bone remodeling in regenerative approaches. In: ACTA BIOMATERIALIA, vol. 108, pp. 22-45. ISSN 1742-7061 Download fulltext
Montalbano, Giorgia; Borciani, Giorgia; Cerqueni, Giorgia; Licini, Caterina; Banche ... (2020)
Collagen Hybrid Formulations for the 3D Printing of Nanostructured Bone Scaffolds: An Optimized Genipin-Crosslinking Strategy. In: NANOMATERIALS, vol. 10. ISSN 2079-4991 Download fulltext
Berkmann, Julia C.; Herrera Martin, Aaron X.; Pontremoli, Carlotta; Zheng, Kai; Bucher, ... (2020)
In Vivo Validation of Spray-Dried Mesoporous Bioactive Glass Microspheres Acting as Prolonged Local Release Systems for BMP-2 to Support Bone Regeneration. In: PHARMACEUTICS, vol. 12. ISSN 1999-4923 Download fulltext
Baino, F.; Caddeo, S.; Vitale Brovarone, C. (2020)
Sintering effects of bioactive glass incorporation in tricalcium phosphate scaffolds. In: MATERIALS LETTERS, vol. 274. ISSN 0167-577X
MONTALBANO, GIORGIA; MOLINO, GIULIA; FIORILLI, SONIA LUCIA; VITALE BROVARONE, CHIARA (2020)
Synthesis and incorporation of rod-like nano-hydroxyapatite into type I collagen matrix: a hybrid formulation for 3D printing of bone scaffolds. In: JOURNAL OF THE EUROPEAN CERAMIC SOCIETY. ISSN 0955-2219 Download fulltext
Molino, Giulia; Palmieri, MARIA CHIARA; Montalbano, Giorgia; Fiorilli, SONIA LUCIA; ... (2020)
Biomimetic and mesoporous nano-hydroxyapatite for bone tissue application: a short review. In: BIOMEDICAL MATERIALS, vol. 15. ISSN 1748-6041 Download fulltext
Licini, C.; Vitale Brovarone, C.; Mattioli-Belmonte, M. (2019)
Collagen and non-collagenous proteins molecular crosstalk in the pathophysiology of osteoporosis. In: CYTOKINE & GROWTH FACTOR REVIEWS, vol. 49, pp. 59-69. ISSN 1359-6101 Download fulltext
PONTREMOLI, CARLOTTA; PERETTI, ENRICO; BARI, ALESSANDRA; Izquierdo-Barba, Isabel; ... (2019)
Mesoporous bioactive glasses as multifunctional devices for bone regeneration. In: 2nd Global Forum on Advanced Materials and Technologies for Sustainable Development (GFMAT-2) and the 4th International Conference on Innovations in Biomaterials, Biomanufacturing, and Biotechnologies (Bio-4), Toronto (Canada), July 21–26, 2019 Download fulltext
Zheng, K.; Balasubramanian, P.; Paterson, T. E.; Stein, R.; MacNeil, S.; Fiorilli, S.; ... (2019)
Ag modified mesoporous bioactive glass nanoparticles for enhanced antibacterial activity in 3D infected skin model. In: MATERIALS SCIENCE AND ENGINEERING. C, BIOMIMETIC MATERIALS, SENSORS AND SYSTEMS, vol. 103. ISSN 0928-4931 Download fulltext
Banche Niclot, Federica; Fiorilli, Sonia Lucia; Vitale Brovarone, Chiara (2019)
Large-pore mesoporous bioactive glasses for bone growth factor encapsulation and release. In: XVIth conference of the European Ceramic Society (ECerS), Torino, 16-20 June
Vitale Brovarone, C.; Verne', E.; Bosetti, M.; Appendino, P.; Cannas, M. (2005)
Microstructural and in vitro characterization of SiO2-Na 2O-CaO-MgO glass-ceramic bioactive scaffolds for bone substitutes. In: JOURNAL OF MATERIALS SCIENCE. MATERIALS IN MEDICINE, vol. 16, pp. 909-917. ISSN 0957-4530
Momete, D. -C.; Verne, E.; Vitale Brovarone, C.; Malucelli, G.; Vasilescu, D. S. (2005)
Polymerization shrinkage in the case of a novel dental composite with polymeric matrix. In: SCIENTIFIC BULLETIN - "POLITEHNICA" UNIVERSITY OF BUCHAREST. SERIES B, CHEMISTRY AND MATERIALS SCIENCE, vol. 67, pp. 15-20. ISSN 1454-2331
Onida, B.; Cauda, V.; Fiorilli, S.; Verne, E.; Brovarone, C. V.; Viterbo, D.; Croce, G.; ... (2005)
Incorporation of ordered mesoporous silica inside a bioactive porous scaffold in view of controlled drug release. In: Studies in Surface Science and Catalysis / S.N., S.L., Elsevier Inc., pp. 2027-2032
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Funded research projects

Active aGeIng and Osteoporosis: The next challenge for smarT nanobiOmaterials and 3D technologies, (2019-2023) - Responsabile Scientifico

Ricerca UE (non commerciale). Progetti di Ricerca Europei

Abstract

The concept behind GIOTTO is to develop a platform of technologies and materials for the treatment of different types of osteoporotic fractures, designing, manufacturing and validating three different solutions:1) 3D graded scaffold, which can be fixated with screws, to treat long bone fractures 2) Fibrous scaffold to deal with small, not confined pelvic fractures;3) Radiopaque, bioresorbable, injectable cement to stabilise vertebral fractures.The three devices will share smart nanobiomaterials that release chemical and biological cues to stimulate bone regeneration while reducing bone loss. Nanofunctionalisation and the smart, temporalised release of active molecules will allow for the systematic cell recruitment and activation needed to face the challenges of stimulating bone tissue regeneration in the elderly. The use of additive manufacturing technologies will enable device personalisation to match and better align with the patient’s anatomy and fracture type. A further boost to meet patient specificity and needs, will be provided through the use of functionalised magnetic nanoparticles in order to provide, via the application of an external oscillating magnetic field, a remote tool to activate mechanotransduction. In parallel, an Internet of Things platform will be developed to gather and collate measurable data inputs about device effectiveness and to provide decision support software as a service to improve the design, manufacture and clinical function of the proposed devices, ultimately managing the overall value chain.

Countries

  • ITALIA

Departments

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Assegnazione del Contributo CRT destinato ai docenti che hanno superato il primo step di valutazione ERC senza aver ottenuto il finanziamento., (2016-2018) - Responsabile Scientifico

Ricerca da Enti privati e Fondazioni (non commerciale). Progetti di Ricerca su Fondi Strutturali e Nazionali

Abstract

Iniziativa per il supporto dell’indipendenza scientifica dei giovani ricercatori, asse a supporto dell’avvio di progetti di ricerca di ricercatori dell’Ateneo che abbiano superato il primo dei due step di valutazione del prestigioso programma europeo ERC di Horizon 2020, ma non siano risultati al termine finanziati.

Countries

  • ITALIA

Institutes/Companies

  • FONDAZIONE CRT CASSA DI RISPARMIO DI TORINO

Departments

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Biomimetic trick to re-balance Osteblast-Osteoclast loopin osteoporoSis treatment: a Topological and materials driven approach , (2016-2021) - Responsabile Scientifico

Ricerca UE (non commerciale). Progetti di Ricerca Europei

Abstract

One out of 5 people in their fifties will experience a bone fracture due to osteoporosis (OP)-induced fragility in theirlifetime. The OP socio-economic burden is dramatic and involves tens of millions of people in the EU, with a steadilyincreasing number due to population ageing. Current treatments entail drug-therapy coupled with a healthy lifestylebut OP fractures need mechanical fixation to rapidly achieve union: the contribution of biomaterial scientists in thisfield is still far from taking its expected leading role in cutting-edge research. Bone remodelling is a well-coordinatedprocess of bone resorption by osteoclasts followed by the production of new bone by osteoblasts. This process occurscontinuously throughout life in a coupling with a positive balance during growth and negative with ageing, whichcan result in OP. We believe that an architecture driven stimulation of the osteoclast/osteoblast coupling, with anavant-garde focus on osteoclasts activity, is the key to success in treating unbalanced bone remodelling. We aim tomanufacture a scaffold that mimics healthy bone features which will establish a new microenvironment favoring aproperly stimulated and active population of osteoclasts and osteoblasts, i.e. a well-balanced bone cooperation. After5 years we will be able to prove the efficacy of this approach. A benchmark will be set up for OP fracture treatmentand for the realization of smart bone substitutes that will be able to locally “trick” aged bone cells stimulating themto act as healthy ones. BOOST results will have an unprecedented impact on the scientific research community,opening a new approach to set up smart, biomimetic strategies to treat aged, unbalanced bone tissues and to reduceOP-associated disabilities and financial burdens.

Countries

  • BELGIO
  • ITALIA

Institutes/Companies

  • COMMISSIONE EUROPEA

Departments

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MOZART-MesopOrous matrices for localiZed pH-triggered releAse of theRapeuTic ions and drugs, (2015-2019) - Responsabile Scientifico

Ricerca UE (non commerciale). Progetti di Ricerca Europei

Abstract

The concept behind MOZART is to develop a library of inorganic nanomatrices to be used as smart platforms for effective, non-invasive and highly targeted therapies. MOZART will address, as proof of concept, nanomatrices to treat delayed bone healing and non-healing chronic skin wounds, which are both characterised by an inflammation and often infection. Mesoporous therapeutic glasses (MTGs), doped with selected ions (e.g. Ag+, Li+, Cu2+, Sr2+, Ce3+, B3+) and having nanopores of adjustable size within 2-50 nm, will be synthesised and then loaded with the chosen payload. Ordered mesoporous carbons (OMCs) will also be manufactured to host a wide range of biomolecules and higher payload. As in an orchestra, where the integration among the different participants allows a harmonious symphony to be created, in MOZART the synergistic release of ions and drugs will be directed to achieve a radically improved therapeutic effect. The exploitation of the response of self-immolative polymer coatings upon pH changes will be used as an elegant and effective way for triggering the payload release. The (coated) nanomatrices will be incorporated in a thermosensitive gel that is liquid at room temperature and undergoes sol-gel transition in the physiological environment. These gels are perfect candidates to develop non-invasive procedures to introduce MOZART nanomatrices to the pathological site and keep them in place for the required time. Clinical and societal impacts of MOZART will be enormous, considering the extraordinarily high number of pathological cases potentially involved. Only in EU, 350 000 patients per year are affected by non-union bone fractures and 2.2 million people suffer from chronic wounds. We expect that MOZART approaches will significantly reduce the healing time of non-union bone fractures (within 4 months vs. a minimum of 12 months) and will allow at least 50% of people suffering from chronic wounds to heal fully.

Countries

  • BELGIO
  • ITALIA

Institutes/Companies

  • COMMISSIONE EUROPEA

Departments

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Valutazione della calcificazione di due valvole biologiche, (2014-2014) - Responsabile Scientifico

Consulenza commerciale. Consulenze e Contratti di ricerca

Countries

  • ITALIA

Institutes/Companies

  • Life and Device S.r.l.

Departments

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MATCH - MONOBLOCK ACETABULAR CUP WITH TRABECULAR-LIKE COATING, (2011-2013) - Responsabile Scientifico

Ricerca UE (non commerciale). Progetti di Ricerca Europei

Countries

  • ITALIA

Institutes/Companies

  • POLITECNICO DI TORINO - AMMINISTRAZIONE CENTRALE

Departments

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FIBRE INORGANICHE BIORIASSORBIBILI PER LA RIGENERAZIONE DEI NERVI PERIFERICI, (2009-2010) - Responsabile Scientifico

Ricerca Regionale (non commerciale). Progetti di Ricerca su Fondi Strutturali e Nazionali

Countries

  • ITALIA

Institutes/Companies

  • Regione Piemonte

Departments

  • Dipartimento di Scienza dei Materiali e Ingegneria Chimica
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SCAFFOLD BIORIASSORBIBILI AD ELEVATA BIOCOMPATIBILITA' PER LA RIGENERAZIONE DEL TESSUTO MUSCOLARE SCHELETRICO (BANDO RICERCA SANITARIA FINALIZZATA BANDO 2007), (2007-2009) - Responsabile Scientifico

Ricerca Regionale (non commerciale). Progetti di Ricerca su Fondi Strutturali e Nazionali

Countries

  • ITALIA

Institutes/Companies

  • Regione Piemonte

Departments

  • Dipartimento di Scienza dei Materiali e Ingegneria Chimica
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FUNZIONALIZZAZIONE DI MATERIALI VETROSI AD AZIONE ATIBATTERICA PER DISPOSITIVI DI OSTEOSINTESI, (2006-2008) - Responsabile Scientifico

Ricerca Regionale (non commerciale). Progetti di Ricerca su Fondi Strutturali e Nazionali

Countries

  • ITALIA

Institutes/Companies

  • UNIVERSITA' DEGLI STUDI DI TORINO
  • Regione Piemonte
  • POLITECNICO DI TORINO - AMMINISTRAZIONE CENTRALE

Departments

  • Dipartimento di Scienza dei Materiali e Ingegneria Chimica
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