FRANCESCA FRASCELLA

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Assistant Professor with time contract

Member of Interdepartmental Center (PolitoBIOMed Lab - Biomedical Engineering Lab)

+39 0110907412 / 7412 (DISAT)

Institute Institute of fundamental Physics and Materials for Nanotechnology
Research groups/teams MPMNT - Materials and Processes for Micro & Nano Technologies
Laboratories
Research projects

Funded by competitive calls

  • Controllare il Cronico per Prevenire il covid-19 , (2020-2021) - Responsabile Scientifico

    National Research

    ERC sectors

    LS2_10 - Bioinformatics LS7_1 - Medical engineering and technology

    SDG

    Obiettivo 3. Assicurare la salute e il benessere per tutti e per tutte le età

    Abstract

    L’infiammazione è il denominatore comune sia della silente pandemia di malattie non trasmissibili (MNT: tumori, autoimmunità; WHO Bulletin, Saha et al., 2017) che di covid-19, tra loro legate poiché l’infiammazione cronica tipica delle MNT è terreno tragicamente fertile per mortalità da covid-19.Nell’attesa di un efficace vaccino, in fasi post-lockdown e/o preventive di nuove emergenze, la protezione dei soggetti fragili tramite l’efficientamento di terapie con dispositivi biomedicali già approvati (stimolazione ottica ed elettrica, la dose), offre un’implementazione potenzialmente molto rapida, di costo contenuto ed effetti collaterali generalmente assenti. Grazie a stampa 3D, NGS e “network medicine” caratterizzeremo sistematicamente gli effetti di questi stimoli, riletti alla luce della funzione normalizzante del wound healing (efficacia), offrendo indicazioni operative per la prescrizione di terapia anti-infiammatoria, di rilievo amplificato nell’immediato e medio-lungo termine.

    Departments

  • Reversible 3D light-structuring of stimuli-responsive hydrogel networks for biophotonic applications, (2017-2019) - Responsabile Scientifico

    Corporate-funded and donor-funded research

    Abstract

    In HYDROLIGHT new technologies for a light-driven, reversible and dynamic micro-patterning of functional polymeric materials are explored, with applications relevant in life science, such as smart substrates for cell growth.We focus on polymers exhibiting light responsivity upon laser irradiation, thanks to the presence of azobenzene units, which are known to show mass-migration driven by radiation. In order to address the ambitious and still unreached goal of controlling mass transport in volume in a stable and reversible manner, new azo-compounds will be investigated. A possible approach relies on soft hydrogels materials composed by azopolymers forming host-guest complexes with ?-cyclodextrine (?-CD) terminated polymeric chain. The mass-migration is controlled through a light-switchable, reversible crosslink (based on the isomerization of the azobenzene) between polymeric chains, allowing an azobenzene-?-CD complex formation.Holographic methods based on programmable Spatial Light Modulators are used to produce 3D light patterns, in such a way that the morphological modifications induced within the hydrogel can dynamically and reversibly conform to the desired light pattern projected. Provided biocompatibility, these stimuli-responsive materials are employed as 3D cell substrates, wherein living cells are seeded. Furthermore, light patterns are produced at visible wavelengths (larger than 530 nm) in such a way that cells seeded into the AzoGel substrate are not severely harmed upon irradiation. A controlled photo-mechanical conditioning of the cell culture will be then performed during the cell growth, by using a dynamic holographic irradiation of the material. The true scientific breakthrough results in the non-invasive dynamic control of the 3D morphology of soft polymers under structured illumination.

    Countries

    • ITALIA

    Institutes/Companies

    • FONDAZIONE COMPAGNIA DI SAN PAOLO

    Departments

Funded by commercial contracts

  • Convenzione di interesse dipartimentale tra il Politecnico di Torino (DISAT) e Silk Materials, per la reciproca collaborazione in attività di ricerca, didattica e formazione nei settori delle micro e nanotecnologie con particolare riferimento allo sviluppo di bio-inchiostri e membrane elettrofilate a base di polimeri naturali per stampa 3D cellulare, di interesse nel campo biomedicale, (unknown date-unknown date) - Responsabile Scientifico

    Departmental agreements

    Countries

    • ITALIA

    Institutes/Companies

    • SILK BIOMATERIALS S.R.L